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Endogenous hepcidin synthesis protects the distal nephron against hemin and hemoglobin mediated necroptosis

Hemoglobinuria is associated with kidney injury in various hemolytic pathologies. Currently, there is no treatment available and its pathophysiology is not completely understood. Here we studied the potential detrimental effects of hemoglobin (Hb) exposure to the distal nephron (DN). Involvement of...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Death Dis
Egile Nagusiak: van Swelm, Rachel P. L., Vos, Madelon, Verhoeven, Frank, Thévenod, Frank, Swinkels, Dorine W.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2018
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5945780/
https://ncbi.nlm.nih.gov/pubmed/29749404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0568-z
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