Endogenous hepcidin synthesis protects the distal nephron against hemin and hemoglobin mediated necroptosis

Hemoglobinuria is associated with kidney injury in various hemolytic pathologies. Currently, there is no treatment available and its pathophysiology is not completely understood. Here we studied the potential detrimental effects of hemoglobin (Hb) exposure to the distal nephron (DN). Involvement of...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Death Dis
Prif Awduron: van Swelm, Rachel P. L., Vos, Madelon, Verhoeven, Frank, Thévenod, Frank, Swinkels, Dorine W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5945780/
https://ncbi.nlm.nih.gov/pubmed/29749404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0568-z
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