Endogenous hepcidin synthesis protects the distal nephron against hemin and hemoglobin mediated necroptosis

Hemoglobinuria is associated with kidney injury in various hemolytic pathologies. Currently, there is no treatment available and its pathophysiology is not completely understood. Here we studied the potential detrimental effects of hemoglobin (Hb) exposure to the distal nephron (DN). Involvement of...

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Udgivet i:Cell Death Dis
Main Authors: van Swelm, Rachel P. L., Vos, Madelon, Verhoeven, Frank, Thévenod, Frank, Swinkels, Dorine W.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5945780/
https://ncbi.nlm.nih.gov/pubmed/29749404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0568-z
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