The p53 activator overcomes resistance to ALK inhibitors by regulating p53-target selectivity in ALK-driven neuroblastomas

Anaplastic lymphoma kinase (ALK) is an oncogenic receptor tyrosine kinase that is activated by gene amplification and mutation in neuroblastomas. ALK inhibitors can delay the progression of ALK-driven cancers, but are of limited use owing to ALK inhibitor resistance. Here, we show that resistance to...

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Pubblicato in:Cell Death Discov
Autori principali: Miyazaki, Makoto, Otomo, Ryo, Matsushima-Hibiya, Yuko, Suzuki, Hidenobu, Nakajima, Ayana, Abe, Naomi, Tomiyama, Arata, Ichimura, Koichi, Matsuda, Koichi, Watanabe, Toshiki, Ochiya, Takahiro, Nakagama, Hitoshi, Sakai, Ryuichi, Enari, Masato
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5945735/
https://ncbi.nlm.nih.gov/pubmed/29760954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-018-0059-0
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