TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression

TGF-β/Activin induces epithelial-to-mesenchymal transition and stemness in pancreatic ductal adenocarcinoma (PDAC). However, the microRNAs (miRNAs) regulated during this response have remained yet undetermined. Here, we show that TGF-β transcriptionally induces MIR100HG lncRNA, containing miR-100, m...

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書誌詳細
出版年:Nat Commun
主要な著者: Ottaviani, Silvia, Stebbing, Justin, Frampton, Adam E., Zagorac, Sladjana, Krell, Jonathan, de Giorgio, Alexander, Trabulo, Sara M., Nguyen, Van T. M., Magnani, Luca, Feng, Hugang, Giovannetti, Elisa, Funel, Niccola, Gress, Thomas M., Jiao, Long R., Lombardo, Ylenia, Lemoine, Nicholas R., Heeschen, Christopher, Castellano, Leandro
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2018
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5945639/
https://ncbi.nlm.nih.gov/pubmed/29748571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03962-x
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