Leptin increases mitochondrial OPA1 via GSK3-mediated OMA1 ubiquitination to enhance therapeutic effects of mesenchymal stem cell transplantation

Accumulating evidence revealed that mesenchymal stem cells (MSCs) confer cardioprotection against myocardial infarction (MI). However, the poor survival and engraftment rate of the transplanted cells limited their therapeutic efficacy in the heart. The enhanced leptin production associated with hypo...

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Udgivet i:Cell Death Dis
Main Authors: Yang, Fan, Wu, Rongrong, Jiang, Zhi, Chen, Jinghai, Nan, Jinliang, Su, Sheng’an, Zhang, Na, Wang, Chen, Zhao, Jing, Ni, Cheng, Wang, Yingchao, Hu, Wangxing, Zeng, Zhiru, Zhu, Keyang, Liu, Xianbao, Hu, Xinyang, Zhu, Wei, Yu, Hong, Huang, Jinyu, Wang, Jian’an
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5945599/
https://ncbi.nlm.nih.gov/pubmed/29748581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0579-9
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