Structural basis for cofilin binding and actin filament disassembly

Actin depolymerizing factor (ADF) and cofilin accelerate actin dynamics by severing and disassembling actin filaments. Here, we present the 3.8 Å resolution cryo-EM structure of cofilactin (cofilin-decorated actin filament). The actin subunit structure of cofilactin (C-form) is distinct from those o...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Tanaka, Kotaro, Takeda, Shuichi, Mitsuoka, Kaoru, Oda, Toshiro, Kimura-Sakiyama, Chieko, Maéda, Yuichiro, Narita, Akihiro
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5945598/
https://ncbi.nlm.nih.gov/pubmed/29749375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04290-w
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