The HDAC inhibitor SAHA regulates CBX2 stability via a SUMO-triggered ubiquitin-mediated pathway in leukemia

Polycomb group (PcG) proteins regulate transcription, playing a key role in stemness and differentiation. Deregulation of PcG members is known to be involved in cancer pathogenesis. Emerging evidence suggests that CBX2, a member of the PcG protein family, is overexpressed in several human tumors, co...

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Publicat a:Oncogene
Autors principals: Di Costanzo, Antonella, Del Gaudio, Nunzio, Conte, Lidio, Dell’Aversana, Carmela, Vermeulen, Michiel, de Thé, Hugues, Migliaccio, Antimo, Nebbioso, Angela, Altucci, Lucia
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5945585/
https://ncbi.nlm.nih.gov/pubmed/29467492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0143-1
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