MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma

The MYC oncogenes and p53 have opposing yet interrelated roles in normal development and tumorigenesis. How MYCN expression alters the biology and clinical responsiveness of pediatric neuroblastoma remains poorly defined. Neuroblastoma is p53 wild type at diagnosis and repression of p53 signaling is...

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Vydáno v:Oncotarget
Hlavní autoři: Agarwal, Saurabh, Milazzo, Giorgio, Rajapakshe, Kimal, Bernardi, Ronald, Chen, Zaowen, Barberi, Eveline, Koster, Jan, Perini, Giovanni, Coarfa, Cristian, Shohet, Jason M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5945521/
https://ncbi.nlm.nih.gov/pubmed/29755654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24859
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