Inhibition of mTOR complex 2 restrains tumor angiogenesis in multiple myeloma

The mammalian Target of Rapamycin (mTOR) is an intracellular serine/threonine kinase that mediates intracellular metabolism, cell survival and actin rearrangement. mTOR is made of two independent complexes, mTORC1 and mTORC2, activated by the scaffold proteins RAPTOR and RICTOR, respectively. The ac...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Lamanuzzi, Aurelia, Saltarella, Ilaria, Desantis, Vanessa, Frassanito, Maria Antonia, Leone, Patrizia, Racanelli, Vito, Nico, Beatrice, Ribatti, Domenico, Ditonno, Paolo, Prete, Marcella, Solimando, Antonio Giovanni, Dammacco, Francesco, Vacca, Angelo, Ria, Roberto
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5945497/
https://ncbi.nlm.nih.gov/pubmed/29755672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25003
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