Inhibition of mTOR complex 2 restrains tumor angiogenesis in multiple myeloma

The mammalian Target of Rapamycin (mTOR) is an intracellular serine/threonine kinase that mediates intracellular metabolism, cell survival and actin rearrangement. mTOR is made of two independent complexes, mTORC1 and mTORC2, activated by the scaffold proteins RAPTOR and RICTOR, respectively. The ac...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lamanuzzi, Aurelia, Saltarella, Ilaria, Desantis, Vanessa, Frassanito, Maria Antonia, Leone, Patrizia, Racanelli, Vito, Nico, Beatrice, Ribatti, Domenico, Ditonno, Paolo, Prete, Marcella, Solimando, Antonio Giovanni, Dammacco, Francesco, Vacca, Angelo, Ria, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5945497/
https://ncbi.nlm.nih.gov/pubmed/29755672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25003
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