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PRC1 fine-tunes gene repression and activation to safeguard skin development and stem cell specification
Polycomb repressive complexes (PRC) 1 and 2 are essential chromatin regulators of cell identity. PRC1, a dominant executer of Polycomb-mediated control, functions as multiple sub-complexes that possess catalytic-dependent H2AK119 mono-ubiquitination (H2AK119ub) and catalytic-independent activities....
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| Publicado no: | Cell Stem Cell |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5944606/ https://ncbi.nlm.nih.gov/pubmed/29727681 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.04.005 |
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