Initial Clinical Experience with AZD5718, a Novel Once Daily Oral 5‐Lipoxygenase Activating Protein Inhibitor

We evaluated safety, tolerability, pharmacokinetics, and pharmacodynamics of AZD5718, a novel 5‐lipooxygenase activating protein (FLAP) inhibitor, in a randomized, single‐blind, placebo‐controlled, first‐in‐human (FIH) study consisting of single and multiple ascending dosing (SAD and MAD) for 10 day...

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Veröffentlicht in:Clin Transl Sci
Hauptverfasser: Ericsson, Hans, Nelander, Karin, Lagerstrom‐Fermer, Maria, Balendran, Clare, Bhat, Maria, Chialda, Ligia, Gan, Li‐Ming, Heijer, Maria, Kjaer, Magnus, Lambert, John, Lindstedt, Eva‐Lotte, Forsberg, Gun‐Britt, Whatling, Carl, Skrtic, Stanko
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5944575/
https://ncbi.nlm.nih.gov/pubmed/29517132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12546
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