Competition of Charge-Mediated and Specific Binding by Peptide-Tagged Cationic Liposome–DNA Nanoparticles In Vitro and In Vivo

Cationic liposome–nucleic acid (CL–NA) complexes, which form spontaneously, are a highly modular gene delivery system. These complexes can be sterically stabilized via PEGylation [PEG: poly(ethylene glycol)] into nanoparticles (NPs) and targeted to specific tissues and cell types via the conjugation...

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Pubblicato in:Biomaterials
Autori principali: Wonder, Emily, Simón-Gracia, Lorena, Scodeller, Pablo, Majzoub, Ramsey N., Kotamraju, Venkata Ramana, Ewert, Kai K., Teesalu, Tambet, Safinya, Cyrus R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5944340/
https://ncbi.nlm.nih.gov/pubmed/29544111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2018.02.052
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