Counteraction of Oxidative Stress by Vitamin E Affects Epigenetic Regulation by Increasing Global Methylation and Gene Expression of MLH1 and DNMT1 Dose Dependently in Caco-2 Cells

Obesity- or diabetes-induced oxidative stress is discussed as a major risk factor for DNA damage. Vitamin E and many polyphenols exhibit antioxidative activities with consequences on epigenetic regulation of inflammation and DNA repair. The present study investigated the counteraction of oxidative s...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Zappe, Katja, Pointner, Angelika, Switzeny, Olivier J., Magnet, Ulrich, Tomeva, Elena, Heller, Jutta, Mare, George, Wagner, Karl-Heinz, Knasmueller, Siegfried, Haslberger, Alexander G.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5944233/
https://ncbi.nlm.nih.gov/pubmed/29854080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/3734250
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