Nonclinical and clinical pharmacological characterization of the potent and selective cathepsin K inhibitor MIV-711

BACKGROUND: Cathepsin K is an attractive therapeutic target for diseases in which bone resorption is excessive such as osteoporosis and osteoarthritis (OA). The current paper characterized the pharmacological profile of the potent and selective cathepsin K inhibitor, MIV-711, in vitro and in cynomol...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Lindström, Erik, Rizoska, Biljana, Henderson, Ian, Terelius, Ylva, Jerling, Markus, Edenius, Charlotte, Grabowska, Urszula
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5944028/
https://ncbi.nlm.nih.gov/pubmed/29743078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-018-1497-4
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