The selective cathepsin K inhibitor MIV-711 attenuates joint pathology in experimental animal models of osteoarthritis

BACKGROUND: MIV-711 is a highly potent and selective cathepsin K inhibitor. The current article summarizes the therapeutic effects of MIV-711 on joint pathology in rabbits subjected to anterior cruciate ligament transection (ACLT), and the prophylactic effects on joint pathology in dogs subjected to...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Lindström, Erik, Rizoska, Biljana, Tunblad, Karin, Edenius, Charlotte, Bendele, Alison M., Maul, Don, Larson, Michael, Shah, Neha, Yoder Otto, Valerie, Jerome, Chris, Grabowska, Urszula
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5845353/
https://ncbi.nlm.nih.gov/pubmed/29523155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-018-1425-7
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