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Mitochondrial DNA damage associated molecular patterns in ventilator-associated pneumonia: Prevention and reversal by intratracheal DNase I

BACKGROUND: Previous studies in isolated perfused rat lungs have revealed that endothelial barrier disruption after intratracheal administration of Pseudomonas aeruginosa (strain 103; PA103) only occurs after accumulation of extracellular mitochondrial DNA (mtDNA) damage-associated molecular pattern...

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Bibliografiske detaljer
Udgivet i:J Trauma Acute Care Surg
Main Authors: Simmons, Jon D., Freno, Daniel R., Muscat, C. Annie, Obiako, Boniface, Lee, Yann-leei L., Pastukh, Viktor M., Brevard, Sidney B., Gillespie, Mark N.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5943707/
https://ncbi.nlm.nih.gov/pubmed/27787436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TA.0000000000001269
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