Trafficking, localization and degradation of the Na(+),HCO(3)(−) co-transporter NBCn1 in kidney and breast epithelial cells

The Na+;HCO3(−) co-transporter NBCn1 (SLC4A7) is a major regulator of intracellular pH yet its trafficking and turnover are essentially unstudied. Here, we used MDCK-II and MCF-7 cells to investigate these processes in epithelial cells. GFP-NBCn1 membrane localization was abolished by truncation of...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Olesen, Christina Wilkens, Vogensen, Jens, Axholm, Ida, Severin, Marc, Schnipper, Julie, Pedersen, Isabella Skandorff, von Stemann, Jakob Hjorth, Schrøder, Jacob Morville, Christensen, Dan Ploug, Pedersen, Stine Falsig
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5943355/
https://ncbi.nlm.nih.gov/pubmed/29743600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25059-7
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