Poloxamer 188 decreases membrane toxicity of mutant SOD1 and ameliorates pathology observed in SOD1 mouse model for ALS

Here we report a gain in function for mutant (mt) superoxide dismutase I (SOD1), a cause of familial amyotrophic lateral sclerosis (FALS), wherein small soluble oligomers of mtSOD1 acquire a membrane toxicity. Phosphatidylglycerol (PG) lipid domains are selectively targeted, which could result in me...

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Detalhes bibliográficos
Publicado no:Neurobiol Dis
Main Authors: Riehm, Jacob J., Wang, Lijun, Ghadge, Ghanashyam, Teng, Michael, Correa, Ana M., Marks, Jeremy D., Roos, Raymond P., Allen, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5943144/
https://ncbi.nlm.nih.gov/pubmed/29627580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2018.03.014
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