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Silencing of transposable elements may not be a major driver of regulatory evolution in primate iPSCs
Transposable elements (TEs) comprise almost half of primate genomes and their aberrant regulation can result in deleterious effects. In pluripotent stem cells, rapidly evolving KRAB-ZNF genes target TEs for silencing by H3K9me3. To investigate the evolution of TE silencing, we performed H3K9me3 ChIP...
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| Foilsithe in: | eLife |
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| Main Authors: | , , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
eLife Sciences Publications, Ltd
2018
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5943035/ https://ncbi.nlm.nih.gov/pubmed/29648536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.33084 |
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