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Characterization of an Anthracene Intermediate in Dynemicin Biosynthesis

Despite the identification of a β-hydroxyhexaene produced by the enediyne polyketide synthases (PKSs), the post-PKS biosynthetic steps to the individual members of this antitumor and antibiotic family remain largely unknown. The massive biosynthetic gene clusters (BGCs) that direct the formation of...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Cohen, Douglas R., Townsend, Craig A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5942901/
https://ncbi.nlm.nih.gov/pubmed/29512267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201802036
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