RELAx – REstricted versus Liberal positive end-expiratory pressure in patients without ARDS: protocol for a randomized controlled trial

BACKGROUND: Evidence for benefit of high positive end-expiratory pressure (PEEP) is largely lacking for invasively ventilated, critically ill patients with uninjured lungs. We hypothesize that ventilation with low PEEP is noninferior to ventilation with high PEEP with regard to the number of ventila...

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Published in:Trials
Main Authors: Algera, Anna Geke, Pisani, Luigi, Bergmans, Dennis C. J., den Boer, Sylvia, de Borgie, Corianne A. J., Bosch, Frank H., Bruin, Karina, Cherpanath, Thomas G., Determann, Rogier M., Dondorp, Arjen M., Dongelmans, Dave A., Endeman, Henrik, Haringman, Jasper J., Horn, Janneke, Juffermans, Nicole P., van Meenen, David M., van der Meer, Nardo J., Merkus, Maruschka P., Moeniralam, Hazra S., Purmer, Ilse, Tuinman, Pieter Roel, Slabbekoorn, Mathilde, Spronk, Peter E., Vlaar, Alexander P. J., Gama de Abreu, Marcelo, Pelosi, Paolo, Serpa Neto, Ary, Schultz, Marcus J., Paulus, Frederique
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
Subjects:
Study Protocol
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5941564/
https://ncbi.nlm.nih.gov/pubmed/29739430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-018-2640-5
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