Sirtuin1 Protects against Systemic Sclerosis–related Pulmonary Fibrosis by Decreasing Proinflammatory and Profibrotic Processes

Pulmonary fibrosis is the leading cause of death in systemic sclerosis (SSc). Sirtuin1 (SIRT1) is a deacetylase with known antiinflammatory and antifibrotic activity in the liver, kidney, and skin. The role of SIRT1 in SSc-related pulmonary fibrosis is unknown. In the present work, we determined tha...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Chu, Haiyan, Jiang, Shuai, Liu, Qingmei, Ma, Yanyun, Zhu, Xiaoxia, Liang, Minrui, Shi, Xiangguang, Ding, Weifeng, Zhou, Xiaodong, Zou, Hejian, Qian, Feng, Shaul, Philip W., Jin, Li, Wang, Jiucun
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5941307/
https://ncbi.nlm.nih.gov/pubmed/28800254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2016-0192OC
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