ATOH1/RFX1/RFX3 transcription factors facilitate the differentiation and characterisation of inner ear hair cell-like cells from patient-specific induced pluripotent stem cells harbouring A8344G mutation of mitochondrial DNA

Degeneration or loss of inner ear hair cells (HCs) is irreversible and results in sensorineural hearing loss (SHL). Human-induced pluripotent stem cells (hiPSCs) have been employed in disease modelling and cell therapy. Here, we propose a transcription factor (TF)-driven approach using ATOH1 and reg...

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Publicado no:Cell Death Dis
Main Authors: Chen, Yen-Chun, Tsai, Chia-Ling, Wei, Yau-Huei, Wu, Yu-Ting, Hsu, Wei-Ting, Lin, Hung-Ching, Hsu, Yi-Chao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5941227/
https://ncbi.nlm.nih.gov/pubmed/29740017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0488-y
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