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Ancient thioredoxins evolved to modern-day stability–function requirement by altering native state ensemble

Thioredoxins (THRXs)—small globular proteins that reduce other proteins—are ubiquitous in all forms of life, from Archaea to mammals. Although ancestral thioredoxins share sequential and structural similarity with the modern-day (extant) homologues, they exhibit significantly different functional ac...

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Detalles Bibliográficos
Publicado en:Philos Trans R Soc Lond B Biol Sci
Main Authors: Modi, Tushar, Huihui, Jonathan, Ghosh, Kingshuk, Ozkan, S. Banu
Formato: Artigo
Idioma:Inglês
Publicado: The Royal Society 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5941179/
https://ncbi.nlm.nih.gov/pubmed/29735738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2017.0184
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