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Signalling networks and dynamics of allosteric transitions in bacterial chaperonin GroEL: implications for iterative annealing of misfolded proteins

Signal transmission at the molecular level in many biological complexes occurs through allosteric transitions. Allostery describes the responses of a complex to binding of ligands at sites that are spatially well separated from the binding region. We describe the structural perturbation method, base...

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Veröffentlicht in:Philos Trans R Soc Lond B Biol Sci
Hauptverfasser: Thirumalai, D., Hyeon, Changbong
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Royal Society 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5941177/
https://ncbi.nlm.nih.gov/pubmed/29735736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2017.0182
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