Evidence of CD4(+) T cell-mediated immune pressure on the Hepatitis C virus genome

Hepatitis C virus (HCV)-specific T cell responses are critical for immune control of infection. Viral adaptation to these responses, via mutations within regions of the virus targeted by CD8(+) T cells, is associated with viral persistence. However, identifying viral adaptation to HCV-specific CD4(+...

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Udgivet i:Sci Rep
Main Authors: Lucas, Michaela, Deshpande, Pooja, James, Ian, Rauch, Andri, Pfafferott, Katja, Gaylard, Elouise, Merani, Shahzma, Plauzolles, Anne, Lucas, Andrew, McDonnell, Wyatt, Kalams, Spyros, Pilkinton, Mark, Chastain, Cody, Barnett, Louise, Prosser, Amy, Mallal, Simon, Fitzmaurice, Karen, Drummer, Heidi, Ansari, M. Azim, Pedergnana, Vincent, Barnes, Ellie, John, Mina, Kelleher, Dermot, Klenerman, Paul, Gaudieri, Silvana
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940905/
https://ncbi.nlm.nih.gov/pubmed/29740042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25559-6
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