Nitrothiophene carboxamides, a novel narrow spectrum antibacterial series: Mechanism of action and Efficacy

The mechanism of efflux is a tour-de-force in the bacterial armoury that has thwarted the development of novel antibiotics. We report the discovery of a novel chemical series with potent antibacterial properties that was engineered to overcome efflux liability. Compounds liable to efflux specificall...

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Publicado no:Sci Rep
Main Authors: Hameed P, Shahul, Bharatham, Nagakumar, Katagihallimath, Nainesh, Sharma, Sreevalli, Nandishaiah, Radha, Shanbhag, Anirudh P., Thomas, Teby, Narjari, Riya, Sarma, Maitrayee, Bhowmik, Purnendu, Amar, Prakruthi, Ravishankar, Rajani, Jayaraman, Ramesh, Muthan, Kubendran, Subbiah, Ramesh, Ramachandran, Vasanthi, Balasubramanian, V., Datta, Santanu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940854/
https://ncbi.nlm.nih.gov/pubmed/29740005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25407-7
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