Hyperactivity of Rac1-GTPase pathway impairs neuritogenesis of cortical neurons by altering actin dynamics

The small-GTPase Rac1 is a key molecular regulator linking extracellular signals to actin cytoskeleton dynamics. Loss-of-function mutations in RAC1 and other genes of the Rac signaling pathway have been implicated in the pathogenesis of Intellectual Disability (ID). The Rac1 activity is negatively c...

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Publicado no:Sci Rep
Main Authors: Zamboni, Valentina, Armentano, Maria, Berto, Gaia, Ciraolo, Elisa, Ghigo, Alessandra, Garzotto, Donatella, Umbach, Alessandro, DiCunto, Ferdinando, Parmigiani, Elena, Boido, Marina, Vercelli, Alessandro, El-Assawy, Nadia, Mauro, Alessandro, Priano, Lorenzo, Ponzoni, Luisa, Murru, Luca, Passafaro, Maria, Hirsch, Emilio, Merlo, Giorgio R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940682/
https://ncbi.nlm.nih.gov/pubmed/29740022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25354-3
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