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Multivalency of NDC80 in the outer kinetochore is essential to track shortening microtubules and generate forces

Presence of multiple copies of the microtubule-binding NDC80 complex is an evolutionary conserved feature of kinetochores, points of attachment of chromosomes to spindle microtubules. This may enable multivalent attachments to microtubules, with implications that remain unexplored. Using recombinant...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Volkov, Vladimir A, Huis in 't Veld, Pim J, Dogterom, Marileen, Musacchio, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940359/
https://ncbi.nlm.nih.gov/pubmed/29629870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.36764
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