Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer

To evaluate whether germline variants in genes encoding pancreatic secretory enzymes contribute to pancreatic cancer susceptibility, we sequenced the coding regions of CPB1 and other genes encoding pancreatic secretory enzymes and known pancreatitis susceptibility genes (PRSS1, CPA1, CTRC, and SPINK...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Tamura, Koji, Yu, Jun, Hata, Tatsuo, Suenaga, Masaya, Shindo, Koji, Abe, Toshiya, MacGregor-Das, Anne, Borges, Michael, Wolfgang, Christopher L., Weiss, Matthew J., He, Jin, Canto, Marcia Irene, Petersen, Gloria M., Gallinger, Steven, Syngal, Sapna, Brand, Randall E., Rustgi, Anil, Olson, Sara H., Stoffel, Elena, Cote, Michele L., Zogopoulos, George, Potash, James B., Goes, Fernando S., McCombie, Richard W., Zandi, Peter P., Pirooznia, Mehdi, Kramer, Melissa, Parla, Jennifer, Eshleman, James R., Roberts, Nicholas J., Hruban, Ralph H., Klein, Alison Patricia, Goggins, Michael
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2018
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5939087/
https://ncbi.nlm.nih.gov/pubmed/29669919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1720588115
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