Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity

Candida albicans is a frequent aetiologic agent of sepsis associated with high mortality in immunocompromised patients. Developing new antifungal therapies is a medical need due to the low efficiency and resistance to current antifungal drugs. Here, we show that p38γ and p38δ regulate the innate imm...

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Publicat a:EMBO Mol Med
Autors principals: Alsina‐Beauchamp, Dayanira, Escós, Alejandra, Fajardo, Pilar, González‐Romero, Diego, Díaz‐Mora, Ester, Risco, Ana, Martín‐Serrano, Miguel A, del Fresno, Carlos, Dominguez‐Andrés, Jorge, Aparicio, Noelia, Zur, Rafal, Shpiro, Natalia, Brown, Gordon D, Ardavín, Carlos, Netea, Mihai G, Alemany, Susana, Sanz‐Ezquerro, Juan J, Cuenda, Ana
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5938613/
https://ncbi.nlm.nih.gov/pubmed/29661910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201708485
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