Cladribine treatment of multiple sclerosis is associated with depletion of memory B cells

BACKGROUND: The mechanism of action of oral cladribine, recently licensed for relapsing multiple sclerosis, is unknown. OBJECTIVE: To determine whether cladribine depletes memory B cells consistent with our recent hypothesis that effective, disease-modifying treatments act by physical/functional dep...

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Publicado en:J Neurol
Autores principales: Ceronie, Bryan, Jacobs, Benjamin M., Baker, David, Dubuisson, Nicolas, Mao, Zhifeng, Ammoscato, Francesca, Lock, Helen, Longhurst, Hilary J., Giovannoni, Gavin, Schmierer, Klaus
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Communication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5937883/
https://ncbi.nlm.nih.gov/pubmed/29550884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00415-018-8830-y
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