RIT1 controls actin dynamics via complex formation with RAC1/CDC42 and PAK1

RIT1 belongs to the RAS family of small GTPases. Germline and somatic RIT1 mutations have been identified in Noonan syndrome (NS) and cancer, respectively. By using heterologous expression systems and purified recombinant proteins, we identified the p21-activated kinase 1 (PAK1) as novel direct effe...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Meyer zum Büschenfelde, Uta, Brandenstein, Laura Isabel, von Elsner, Leonie, Flato, Kristina, Holling, Tess, Zenker, Martin, Rosenberger, Georg, Kutsche, Kerstin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5937737/
https://ncbi.nlm.nih.gov/pubmed/29734338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007370
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