RIT1 controls actin dynamics via complex formation with RAC1/CDC42 and PAK1

RIT1 belongs to the RAS family of small GTPases. Germline and somatic RIT1 mutations have been identified in Noonan syndrome (NS) and cancer, respectively. By using heterologous expression systems and purified recombinant proteins, we identified the p21-activated kinase 1 (PAK1) as novel direct effe...

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Pubblicato in:PLoS Genet
Autori principali: Meyer zum Büschenfelde, Uta, Brandenstein, Laura Isabel, von Elsner, Leonie, Flato, Kristina, Holling, Tess, Zenker, Martin, Rosenberger, Georg, Kutsche, Kerstin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5937737/
https://ncbi.nlm.nih.gov/pubmed/29734338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007370
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