Patatin-like phospholipase domain–containing protein 3 promotes transfers of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets

Fatty liver disease (FLD) is a burgeoning health problem. A missense variant (I148M) in patatin-like phospholipase domain–containing protein 3 (PNPLA3) confers susceptibility to FLD, although the mechanism is not known. To glean first insights into the physiological function of PNPLA3, we performed...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Mitsche, Matthew A., Hobbs, Helen H., Cohen, Jonathan C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Lipids
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936833/
https://ncbi.nlm.nih.gov/pubmed/29555681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002333
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