An activating mutation of interferon regulatory factor 4 (IRF4) in adult T-cell leukemia

The human T-cell leukemia virus-1 (HTLV-1) oncoprotein Tax drives cell proliferation and resistance to apoptosis early in the pathogenesis of adult T-cell leukemia (ATL). Subsequently, probably as a result of specific immunoediting, Tax expression is down-regulated and functionally replaced by somat...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Cherian, Mathew A., Olson, Sydney, Sundaramoorthi, Hemalatha, Cates, Kitra, Cheng, Xiaogang, Harding, John, Martens, Andrew, Challen, Grant A., Tyagi, Manoj, Ratner, Lee, Rauch, Daniel
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936815/
https://ncbi.nlm.nih.gov/pubmed/29540473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000164
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