Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation

Aberrant expression of proteins often underlies many diseases, including cancer. A recently developed approach in drug development is small molecule-mediated, selective degradation of dysregulated proteins. We have devised a protein-knockdown system that utilizes chimeric molecules termed specific a...

詳細記述

保存先:
書誌詳細
出版年:J Biol Chem
主要な著者: Ohoka, Nobumichi, Morita, Yoko, Nagai, Katsunori, Shimokawa, Kenichiro, Ujikawa, Osamu, Fujimori, Ikuo, Ito, Masahiro, Hayase, Youji, Okuhira, Keiichiro, Shibata, Norihito, Hattori, Takayuki, Sameshima, Tomoya, Sano, Osamu, Koyama, Ryokichi, Imaeda, Yasuhiro, Nara, Hiroshi, Cho, Nobuo, Naito, Mikihiko
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2018
主題:
Protein Synthesis and Degradation
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936811/
https://ncbi.nlm.nih.gov/pubmed/29545311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001091
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