Activity and fidelity of human DNA polymerase α depend on primer structure

DNA polymerase α (Polα) plays an important role in genome replication. In a complex with primase, Polα synthesizes chimeric RNA–DNA primers necessary for replication of both chromosomal DNA strands. During RNA primer extension with deoxyribonucleotides, Polα needs to use double-stranded helical subs...

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Vydáno v:J Biol Chem
Hlavní autoři: Baranovskiy, Andrey G., Duong, Vincent N., Babayeva, Nigar D., Zhang, Yinbo, Pavlov, Youri I., Anderson, Karen S., Tahirov, Tahir H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936803/
https://ncbi.nlm.nih.gov/pubmed/29555682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001074
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