Divalent ions attenuate DNA synthesis by human DNA polymerase α by changing the structure of the template/primer or by perturbing the polymerase reaction

DNA polymerases (pols) are sophisticated protein machines operating in the replication, repair and recombination of genetic material in the complex environment of the cell. DNA pol reactions require at least two divalent metal ions for the phosphodiester bond formation. We explore two understudied r...

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Bibliographic Details
Published in:DNA Repair (Amst)
Main Authors: Zhang, Yinbo, Baranovskiy, Andrey G., Tahirov, Emin T., Tahirov, Tahir H., Pavlov, Youri I.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4917474/
https://ncbi.nlm.nih.gov/pubmed/27235627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2016.05.017
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