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Divalent ions attenuate DNA synthesis by human DNA polymerase α by changing the structure of the template/primer or by perturbing the polymerase reaction
DNA polymerases (pols) are sophisticated protein machines operating in the replication, repair and recombination of genetic material in the complex environment of the cell. DNA pol reactions require at least two divalent metal ions for the phosphodiester bond formation. We explore two understudied r...
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| Udgivet i: | DNA Repair (Amst) |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4917474/ https://ncbi.nlm.nih.gov/pubmed/27235627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2016.05.017 |
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