Coenzyme A–mediated degradation of pyruvate dehydrogenase kinase 4 promotes cardiac metabolic flexibility after high-fat feeding in mice

Cardiac energy is produced primarily by oxidation of fatty acids and glucose, with the relative contributions of each nutrient being sensitive to changes in substrate availability and energetic demand. A major contributor to cardiac metabolic flexibility is pyruvate dehydrogenase (PDH), which conver...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Schafer, Christopher, Young, Zachary T., Makarewich, Catherine A., Elnwasany, Abdallah, Kinter, Caroline, Kinter, Michael, Szweda, Luke I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936801/
https://ncbi.nlm.nih.gov/pubmed/29540486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000268
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