CK2 Phosphorylating I(2)(PP2A)/SET Mediates Tau Pathology and Cognitive Impairment

Casein kinase 2 (CK2) is highly activated in Alzheimer disease (AD) and is associated with neurofibrillary tangles formation. Phosphorylated SET, a potent PP2A inhibitor, mediates tau hyperphosphorylation in AD. However, whether CK2 phosphorylates SET and regulates tau pathological phosphorylation i...

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Bibliografski detalji
Izdano u:Front Mol Neurosci
Glavni autori: Zhang, Qing, Xia, Yiyuan, Wang, Yongjun, Shentu, Yangping, Zeng, Kuan, Mahaman, Yacoubou A. R., Huang, Fang, Wu, Mengjuan, Ke, Dan, Wang, Qun, Zhang, Bin, Liu, Rong, Wang, Jian-Zhi, Ye, Keqiang, Wang, Xiaochuan
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2018
Teme:
Neuroscience
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936753/
https://ncbi.nlm.nih.gov/pubmed/29760653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00146
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