BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer’s disease

Amyloid beta (Aβ) is a major pathological marker in Alzheimer’s disease (AD), which is principally regulated by the rate-limiting β-secretase (i.e., BACE1) cleavage of amyloid precursor protein (APP). However, how BACE1 activity is posttranslationally regulated remains incompletely understood. Here,...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bao, Jian, Qin, Min, Mahaman, Yacoubou Abdoul Razak, Zhang, Bin, Huang, Fang, Zeng, Kuan, Xia, Yiyuan, Ke, Dan, Wang, Qun, Liu, Rong, Wang, Jian-Zhi, Ye, Keqiang, Wang, Xiaochuan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899489/
https://ncbi.nlm.nih.gov/pubmed/29581300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1800498115
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