From in silico to in vitro: a trip to reveal flavonoid binding on the Rattus norvegicus Kir6.1 ATP-sensitive inward rectifier potassium channel

BACKGROUND: ATP-sensitive inward rectifier potassium channels (Kir), are a potassium channel family involved in many physiological processes. K(ATP) dysfunctions are observed in several diseases such as hypoglycaemia, hyperinsulinemia, Prinzmetal angina–like symptoms, cardiovascular diseases. METHOD...

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Veröffentlicht in:PeerJ
Hauptverfasser: Trezza, Alfonso, Cicaloni, Vittoria, Porciatti, Piera, Langella, Andrea, Fusi, Fabio, Saponara, Simona, Spiga, Ottavia
Format: Artigo
Sprache:Inglês
Veröffentlicht: PeerJ Inc. 2018
Schlagworte:
Biochemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936070/
https://ncbi.nlm.nih.gov/pubmed/29736333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.4680
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