Brain-Mimetic 3D Culture Platforms Allow Investigation of Cooperative Effects of Extracellular Matrix Features on Therapeutic Resistance in Glioblastoma

Glioblastoma (GBM) tumors exhibit potentially actionable genetic alterations against which targeted therapies have been effective in treatment of other cancers. However, these therapies have largely failed in GBM patients. A notable example is EGFR kinase inhibitors, which display poor clinical effi...

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Опубликовано в: :Cancer Res
Главные авторы: Xiao, Weikun, Zhang, Rongyu, Sohrabi, Alireza, Ehsanipour, Arshia, Sun, Songping, Liang, Jesse, Walthers, Christopher, Ta, Lisa, Nathanson, David A., Seidlits, Stephanie K.
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935550/
https://ncbi.nlm.nih.gov/pubmed/29282221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-2429
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