Brain-Mimetic 3D Culture Platforms Allow Investigation of Cooperative Effects of Extracellular Matrix Features on Therapeutic Resistance in Glioblastoma

Glioblastoma (GBM) tumors exhibit potentially actionable genetic alterations against which targeted therapies have been effective in treatment of other cancers. However, these therapies have largely failed in GBM patients. A notable example is EGFR kinase inhibitors, which display poor clinical effi...

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Publicat a:Cancer Res
Autors principals: Xiao, Weikun, Zhang, Rongyu, Sohrabi, Alireza, Ehsanipour, Arshia, Sun, Songping, Liang, Jesse, Walthers, Christopher, Ta, Lisa, Nathanson, David A., Seidlits, Stephanie K.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935550/
https://ncbi.nlm.nih.gov/pubmed/29282221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-2429
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