Therapeutic Potential of a Prolyl Hydroxylase Inhibitor FG-4592 for Parkinson’s Diseases in Vitro and in Vivo: Regulation of Redox Biology and Mitochondrial Function

As the main transcription factor that regulates the cellular responses to hypoxia, Hypoxia-inducible factor-1α (HIF-1α) plays an important role in the pathogenesis of Parkinson’s disease (PD). HIF-1α is normally degraded through ubiquitination after hydroxylation by prolyl hydroxylases (PHD). Emergi...

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Udgivet i:Front Aging Neurosci
Main Authors: Li, Xuan, Cui, Xin-Xin, Chen, Ya-Jing, Wu, Ting-Ting, Xu, Huaxi, Yin, Huiyong, Wu, Yun-Cheng
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935184/
https://ncbi.nlm.nih.gov/pubmed/29755339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2018.00121
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