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Intraflagellar transport is deeply integrated in hedgehog signaling

The vertebrate hedgehog pathway is organized in primary cilia, and hedgehog components relocate into or out of cilia during signaling. Defects in intraflagellar transport (IFT) typically disrupt ciliary assembly and attenuate hedgehog signaling. Determining whether IFT drives the movement of hedgeho...

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Détails bibliographiques
Publié dans:Mol Biol Cell
Auteurs principaux: Eguether, Thibaut, Cordelieres, Fabrice P., Pazour, Gregory J.
Format: Artigo
Langue:Inglês
Publié: The American Society for Cell Biology 2018
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935068/
https://ncbi.nlm.nih.gov/pubmed/29540531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-10-0600
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