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Ubiquitin links smoothened to intraflagellar transport to regulate Hedgehog signaling

In the absence of Hedgehog ligand, patched-1 (Ptch1) localizes to cilia and prevents ciliary accumulation and activation of smoothened (Smo). Upon ligand binding, Ptch1 is removed from cilia, and Smo is derepressed and accumulates in cilia where it activates signaling. The mechanisms regulating thes...

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Bibliografische gegevens
Gepubliceerd in:J Cell Biol
Hoofdauteurs: Desai, Paurav B., Stuck, Michael W., Lv, Bo, Pazour, Gregory J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Rockefeller University Press 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7337509/
https://ncbi.nlm.nih.gov/pubmed/32435793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201912104
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