Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells

Malignant melanoma incidence has been increasing for over 30 years, and despite promising new therapies, metastatic disease remains difficult to treat. We describe preliminary results from a Phase I clinical trial (NCT01586403) of adoptive cell therapy in which three patients received autologous CD4...

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Vydáno v:Cancer Immunol Immunother
Hlavní autoři: Moore, Tamson, Wagner, Courtney Regan, Scurti, Gina M., Hutchens, Kelli A., Godellas, Constantine, Clark, Ann Lau, Kolawole, Elizabeth Motunrayo, Hellman, Lance M., Singh, Nishant K., Huyke, Fernando A., Wang, Siao-Yi, Calabrese, Kelly M., Embree, Heather D., Orentas, Rimas, Shirai, Keisuke, Dellacecca, Emilia, Garrett-Mayer, Elizabeth, Li, Mingli, Eby, Jonathan M., Stiff, Patrick J., Evavold, Brian D., Baker, Brian M., Le Poole, I. Caroline, Dropulic, Boro, Clark, Joseph I., Nishimura, Michael I.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2017
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935006/
https://ncbi.nlm.nih.gov/pubmed/29052782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-017-2073-0
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